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Researchers Develop Better, Safer Test for Pernicious Anemia
The new test also will allow physicians to rule out Pernicious anemia in patients who have a B12 deficiency caused by vegan diets and diseases such as gastritis. “It’s just not good medicine to say ‘You’re vitamin B12 deficient, you’ll need to take shots for the rest of your life,’” Miller said. “The new test will allow physicians to develop more science-based interventions and direct the most appropriate treatment for patients.”
What Is Pernicious Anemia?
The condition was named Pernicious anemia because it was often fatal in the years before the cause was discovered to be a lack of vitamin B12, and no specific treatments were available. Now it is easy to treat with vitamin B12 pills or injections. Pernicious anemia can be severe if it goes on for a long time without being treated. If it is not treated, it can cause permanent damage to the body. Pernicious anemia is especially common in older adults.
What Causes Pernicious Anemia?
Some people who are strict vegetarians can develop Pernicious anemia, especially if they do not eat meat, poultry, fish, eggs, or dairy products the best food sources of vitamin B12. Breastfed infants of strict vegetarian mothers can develop anemia in a short time because they don t have enough vitamin B12 stored in their bodies. They can be given vitamin B12 supplements to prevent this type of anemia.
Dictionary of Cancer Terms
Dictionary of Cancer Terms
pernicious anemia
Pernicious anemia
Office of Dietary Supplements - HOME
Office of Dietary Supplements - HOME
Definition of pernicious anemia - NCI Dictionary of Cancer Terms
Definition of Pernicious anemia - NCI Dictionary of Cancer Terms
Folic Acid and Pernicious Anemia
Folic Acid and Pernicious Anemia
MedlinePlus
Medical Encyclopedia: Pernicious anemia
Very rarely, infants and children are born without the ability to produce enough intrinsic factor. Congenital (born with) Pernicious anemia is inherited as an autosomal recessive disorder (you need the defective gene from each parent to get it). Most often, however, Pernicious anemia and other forms of megaloblastic anemia in children result from other causes of vitamin B12 deficiency or other vitamin deficiencies.
MedlinePlus: Anemia
MedlinePlus: Anemia
Energy Citations Database (ECD) - - Document #4157889
COBALT ISOTOPES Co-58/ use of vitamin B12-incoporated, for diagnosis of Pernicious anemia in man;MAN/ Pernicious anemia in, evaluation of dual radioisotope urinary excretion test for;DISEASES, PHYSIOLOGICAL/ anemia, radiodiagnosis of Pernicious, in man, use of cobalt-57 and cobalt-58 urinary excretion test for;COBALT ISOTOPES Co-57/ use of vitamin B12-incorporated, for diagnosis of Pernicious anemia in man
Anemia
Vitamin B12 deficiency anemia (or Pernicious [pur-NISH-us] anemia). This type of anemia happens due to a lack of vitamin B12 in the body. Your body needs vitamin B12 to make red blood cells and to keep your nervous system working normally. This type of anemia occurs most often in people whose bodies are not able to absorb vitamin B12 from food because of an autoimmune disorder. It also can happen because of intestinal problems.
Vitamin and Mineral Supplement Fact Sheets
Vitamin and Mineral Supplement Fact Sheets
Section
(b) On the basis of the scientific evidence and conclusions summarized in the statement of the U.S.P. Anti-anemia Preparations Advisory Board as well as pertinent information from other sources, the Commissioner of Food and Drugs finds it is the consensus of well informed medical opinion that: (1) The parenteral administration of cyanocobalamin or vitamin B 12 is generally recognized as a fully effective treatment of Pernicious anemia. Parenteral cyanocobalamin preparations have not been and are not authorized for use except by or on the prescription of a duly licensed medical practitioner. (2) Some patients afflicted with Pernicious anemia do not respond to orally ingested products. There is no known way to predict which patients will fail to respond or will cease to respond to the treatment of Pernicious anemia with orally ingested preparations. (3) The substitution of a possibly inadequate treatment, such as the ingestion of oral preparations of vitamin B 12 with intrinsic factor concentrate, in place of parenteral vitamin B 12 products for a disease condition as serious as Pernicious anemia cannot be regarded as safe in all cases. (4) The development of the classical symptoms of Pernicious anemia that would cause a person to seek medical attention may in some cases be delayed by oral ingestion of intrinsic factor. Pernicious anemia is a disease that is associated, among other things, with a higher than normal incidence of cancer of the stomach and that for the safety of the patient, requires continuous expert medical supervision. (5) With inadequate treatment there may be markedly deleterious effects on the nervous system. It is well established that whereas the development of anemia is completely reversible with adequate treatment, the involvement of the nervous system may not be completely reversible and thus may result in permanent damage. (6) Some hematologists prescribe oral preparations of vitamin B 12 i
Energy Citations Database (ECD) - - Document #4335135
TECHNIQUES FOR Pernicious ANEMIA DIAGNOSIS WITH RADIOCYANOCOBALAMIN
Electronic Code of Federal Regulations:
(e) Any drug for oral ingestion intended, represented, or advertised for the prevention or treatment of Pernicious anemia or which purports to contain any substance or mixture of substances described in paragraph (d) of this section (other than diagnostic drugs containing radioactive cyanocobalamin) will be regarded as misbranded under sections 502 (f)(2) and (j) of the act unless its labeling bears a statement to the effect that some patients afflicted with Pernicious anemia may not respond to the orally ingested product and that there is no known way to predict which patients will respond or which patients may cease to respond to the orally ingested products. The labeling shall also bear a statement that periodic examinations and laboratory studies of Pernicious anemia patients are essential and recommended.
anemia
anemia
NIH - Anemia
What Is Pernicious Anemia?
The Stomach in Pernicious anemia
The Stomach in Pernicious anemia
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