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Search of: "idiopathic anaphylaxis" - List Results - ClinicalTrials.gov
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing
The diagnosis and management of anaphylaxis: an updated practice parameter.
Consider a normal saline intravenous line for fluid replacement and venous access. Lactated Ringer's solution might potentially contribute to metabolic acidosis, and dextrose is rapidly extravasated from the intravascular circulation to the interstitial tissues. Increased vascular permeability in Anaphylaxis might permit transfer of 50% of the intravascular fluid into the extravascular space within 10 minutes. Crystalloid volumes (e.g., saline) of up to 7 L might be necessary. One to 2 L of normal saline should be administered to adults at a rate of 5 to 10 mL/ kg in the first 5 minutes. Patients with congestive heart failure or chronic renal disease should be observed cautiously to prevent volume overload. Children should receive up to 30 mL/ kg in the first hour. Adults receiving colloid solution should receive 500 mL rapidly, followed by slow infusion. Aqueous epinephrine 1:1000, 0.1 to 0.3 mL in 10 mL of normal saline, can be administered intravenously over several minutes and repeated as necessary in cases of Anaphylaxis not responding to epinephrine injections and volume resuscitation. Alternatively, an epinephrine infusion can be prepared by adding 1 mg (1 mL) of a 1:1000 dilution of epinephrine to 250 mL of D5W to yield a concentration of 4.0 micrograms/ mL. This solution is infused at a rate of 1 to 4 micrograms/ min (15 to 60 drops per minute with a microdrop apparatus [60 drops per minute = 1 mL = 60 mL/ h]), increasing to a maximum of 10.0 micrograms/ min. If an infusion pump is available, an alternative 1:100,000 solution of epinephrine (1 mg [1 mL] in 100 mL of saline) can be prepared and administered intravenously at an initial rate of 30 to 100 mL/ h (5 to 15 micrograms/ min), titrated up or down depending on clinical response or epinephrine side effects (toxicity). A dosage of 0.01 mg/ kg (0.1 mL/ kg of a 1:10,000 solution; maximum dose, 0.3 mg) is recommended for children. Alternative pediatric dosage by the "rule of 6" is as follows: 0.6 times bod
MedlinePlus
Medical Encyclopedia: Anaphylaxis
Anaphylaxis is an acute systemic (whole body) type of allergic reaction which occurs when a person has become sensitized to a certain substance or allergen and is again exposed to the allergen. Some drugs, such as those used for pain relief or for X-rays, may cause an anaphylactoid reaction on first exposure. Histamines and other substances released into the bloodstream cause blood vessels to dilate and tissues to swell. Anaphylaxis may be life-threatening if obstruction of the airway occurs, if blood pressure drops, or if heart arrhythmias occur.
healthfinder.gov - Anaphylaxis
This document provides answers to frequently asked questions about Anaphylaxis, a sudden, severe, potentially fatal, systemic allergic reaction that can involve various areas of the body (such as the ... Details >
Lawriter - ORC - 3313.718 Possession and use of epinephrine autoinjector to treat anaphylaxis.
(B) Notwithstanding section 3313.713 of the Revised Code or any policy adopted under that section, a student of a school operated by a city, local, exempted village, or joint vocational school district or a student of a chartered nonpublic school may possess and use an epinephrine autoinjector to treat Anaphylaxis, if all of the following conditions are satisfied:
Search of: anaphylaxis - List Results - ClinicalTrials.gov
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing
20-5-420. Self-administration or possession of asthma, severe allergy, or anaphylaxis medication.
(7) If provided by the parent, an individual who has executed a caretaker relative educational authorization affidavit pursuant to 20-5-503 , an individual who has executed a caretaker relative medical authorization affidavit pursuant to 40-6-502 , or a guardian and in accordance with documents provided by the pupil's physician, physician assistant, or advanced practice registered nurse, asthma, severe allergy, or Anaphylaxis medication may be kept by the pupil and backup medication must be kept at a pupil's school in a predetermined location or locations to which the pupil has access in the event of an asthma, severe allergy, or Anaphylaxis emergency.
ANTIBIOTIC ANAPHYLAXIS
ANTIBIOTIC Anaphylaxis
MedlinePlus
Medical Encyclopedia: Anaphylaxis
Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, et al. Second symposium on the definition and management of Anaphylaxis: summary report-second National Institute of Allergy and Infectious Disease/ Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med . 2006; 47:373-380.
Allergic Reaction Anaphylaxis
Dr. Rivera says, "Our findings about S1P and Anaphylaxis were unexpected. We set out to address what causes mast cells to respond to an allergy-stimulus in vivo." Mast cells are white blood cells that release allergen-fighting substances, such as histamine, during an allergic reaction. "We were using mice that could not produce sphingosine kinase 1 or sphingosine kinase 2," he said, referring to two proteins (also called Sphk1 and Sphk2) that mast cells activate when confronted by allergens. "When we compared their responses with those of normal mice, we found that Anaphylaxis severity correlated with circulating S1P levels."
Passive Cutaneous Anaphylaxis
Passive Cutaneous Anaphylaxis [E01.450.495.750.600]
healthfinder.gov — Food Allergy and Anaphylaxis Network - FAAN
The mission of The Food Allergy & Anaphylaxis Network (FAAN) is to raise public awareness, to provide advocacy and education, and to advance research on behalf of all those affected by food allergies and Anaphylaxis (a life-threatening allergic reaction). FAAN is the world s largest nonprofit organization providing patients information about food allergy and educational resources to schools, health professionals, restaurants, pharmaceutical companies, the food industry, and government officials.
The diagnosis and management of anaphylaxis: an updated practice parameter.
Consider a normal saline intravenous line for fluid replacement and venous access. Lactated Ringer's solution might potentially contribute to metabolic acidosis, and dextrose is rapidly extravasated from the intravascular circulation to the interstitial tissues. Increased vascular permeability in Anaphylaxis might permit transfer of 50% of the intravascular fluid into the extravascular space within 10 minutes. Crystalloid volumes (e.g., saline) of up to 7 L might be necessary. One to 2 L of normal saline should be administered to adults at a rate of 5 to 10 mL/ kg in the first 5 minutes. Patients with congestive heart failure or chronic renal disease should be observed cautiously to prevent volume overload. Children should receive up to 30 mL/ kg in the first hour. Adults receiving colloid solution should receive 500 mL rapidly, followed by slow infusion. Aqueous epinephrine 1:1000, 0.1 to 0.3 mL in 10 mL of normal saline, can be administered intravenously over several minutes and repeated as necessary in cases of Anaphylaxis not responding to epinephrine injections and volume resuscitation. Alternatively, an epinephrine infusion can be prepared by adding 1 mg (1 mL) of a 1:1000 dilution of epinephrine to 250 mL of D5W to yield a concentration of 4.0 micrograms/ mL. This solution is infused at a rate of 1 to 4 micrograms/ min (15 to 60 drops per minute with a microdrop apparatus [60 drops per minute = 1 mL = 60 mL/ h]), increasing to a maximum of 10.0 micrograms/ min. If an infusion pump is available, an alternative 1:100,000 solution of epinephrine (1 mg [1 mL] in 100 mL of saline) can be prepared and administered intravenously at an initial rate of 30 to 100 mL/ h (5 to 15 micrograms/ min), titrated up or down depending on clinical response or epinephrine side effects (toxicity). A dosage of 0.01 mg/ kg (0.1 mL/ kg of a 1:10,000 solution; maximum dose, 0.3 mg) is recommended for children. Alternative pediatric dosage by the "rule of 6" is as follows: 0.6 times bod
Section 167-627 Possession and self-administration of m
(3) The pupil's physician has approved and signed a written treatment plan for managing asthma or Anaphylaxis episodes of the pupil and for medication for use by the pupil. Such plan shall include a statement that the pupil is capable of self-administering the medication under the treatment plan;
RCW 28A.210.370: Students with asthma.
(6) School districts must require that backup medication, if provided by a student's parent or guardian, be kept at a student's school in a location to which the student has immediate access in the event of an asthma or Anaphylaxis emergency.
Abnormal Immune Cells May Cause Unprovoked Anaphylaxis
Abnormal Immune Cells May Cause Unprovoked Anaphylaxis
Abnormal Immune Cells May Cause Unprovoked Anaphylaxis, November 9, 2007 News Release - National Institutes of Health (NIH)
In a two-year study conducted at the NIH Clinical Center, the researchers examined 48 patients diagnosed with mastocytosis with or without associated Anaphylaxis, 12 patients with idiopathic Anaphylaxis, and 12 patients with neither disease. Within the group of 12 patients who had idiopathic Anaphylaxis, five were found with evidence of a disorder in a line of mast cells (clonal mast cell disorder). The researchers looked for evidence of a Kit mutation in three patients by analyzing bone marrow samples, and all three samples yielded a positive result. The findings demonstrate that some patients with idiopathic Anaphylaxis have an aberrant population of mast cells with mutated Kit.
Information for Healthcare Professionals: Omalizumab (marketed as Xolair)
Symptoms and signs of Anaphylaxis in these reported cases included bronchospasm, hypotension, syncope, urticaria, angioedema of the throat or tongue, dyspnea, cough, chest tightness, cutaneous angioedema, and generalized pruritus. Some patients required oxygen and parenteral medications. Pulmonary involvement, including bronchospasm, dyspnea, cough, or chest tightness, was reported in 96% of the cases. Hypotension or syncope was reported in 13% of cases. Fifteen percent of these patients required hospitalization. While most cases of Anaphylaxis (71%) occurred within the first 2 hours after Xolair administration, some (13%) occurred later, up to about 24 hours after administration. Anaphylaxis occurred after the first dose of Xolair in 40% of cases, and after repeat administration in 56% of cases. In some cases, Anaphylaxis was reported after two years of chronic treatment. Five patients who experienced Anaphylaxis were rechallenged with Xolair; all had a recurrence of similar symptoms of Anaphylaxis.
Anaphylaxis: An Allergic Reaction That Can Kill (May 1989)
Despite the numerous foods, chemicals, drugs, and physical precipitators known to cause Anaphylaxis, in most instances the cause of a reaction is unknown (idiopathic). Researchers at Northwestern University Medical School in Chicago recently reported on 73 patients with idiopathic Anaphylaxis. "Idiopathic Anaphylaxis," the researchers wrote in the February 1987 Archives of Internal Medicine," can be extremely frightening to both patient and physician when no inciting source is found. Patients often attribute their symptoms to foods or food additives, and many patients become increasingly frustrated by the unpredictability of their reactions." Three patients followed by the scientists became afraid to eat because they feared it would induce Anaphylaxis. Reassurance helped rid the fear in two of the three. The third patient consulted another physician who performed laboratory tests and advised her not to eat eggs, soybeans, chocolate, or fish. Despite avoiding these foods, she continued to have anaphylactic episodes and lost more than 18 pounds in two years.
ABC of allergies: Anaphylaxis
ABC of allergies: Anaphylaxis
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