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Div. of Anesthesia, Analgesia and Rheumatology Products
Workshop on the Medical Utility of Marijuana
9 -THC or smoking marijuana. The current "FDA Guideline for the Clinical Evaluation of Analgesic Drugs" (FDA 1992) notes that "Evidence is still inadequate to establish that any experimental pain model will consistently and accurately predict the clinical efficacy of new analgesics, . . . [and] they cannot substitute for controlled trials in patients with pathologic pain [naturally occurring pain caused by disease or tissue injury] in producing substantial evidence of Analgesia . . ." This is also the overwhelming consensus of investigators who conduct controlled clinical trials of analgesic efficacy. Therefore, the above studies contribute little information about the analgesic efficacy of marijuana/
Analgesia and Antiinflammatory Drug Development and Therapy
This web site provides information on the approval process and approved therapies for Analgesia and anti-inflammatory related drugs. The Division of Anesthesia, Analgesia, and Rheumatology Products (DAARP) reviews these drugs.
Epidural analgesia in obstetrics.
Epidural Analgesia in obstetrics.
Search of: "Analgesia" - List Results - ClinicalTrials.gov
Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia; Procedure: Epidural labor Analgesia
Search of: "Analgesia" - List Results - ClinicalTrials.gov
Drug: Intrathecal morphine at surgery, 0.1mg and placebo; Drug: Patient Controlled Analgesia with iv morphine and placebo; Drug: intrathecal morphine AND patient controlled Analgesia with iv morphine
Clinical policy: procedural sedation and analgesia in the emergency department.
A MEDLINE search of English-language articles published between January 1992 and January 2004 was performed using combinations of the key words "conscious sedation," "moderate sedation," "deep sedation," "Analgesia," "sedation," "standards," "guidelines," "complications," and "emergency department." Terms were then exploded as appropriate. Abstracts and articles were reviewed by subcommittee members, and pertinent articles were selected. These articles were evaluated, and those addressing the questions considered in this document were chosen for grading. Subcommittee members also supplied references from bibliographies of initially selected articles or from their own files.
Clinical policy: procedural sedation and analgesia in the emergency department.
Clinical Policies Subcommittee (Writing Committee) on Procedural Sedation and Analgesia Members : Steven A. Godwin, MD (Chair); David A. Caro, MD; Stephen J. Wolf, MD; Andy S. Jagoda, MD; Ronald Charles, MD; Benjamin E. Marett, RN, MSN, CEN, CNA, COHN-S (ENA Representative 2002-2003); Jessie Moore, RN, MSN, CEN (ENA Representative 2001-2002)
A Reference Source for Analgesia & Analgesics in Animals,
AWIC Series 2000-02
The Animal Welfare Information Center (AWIC) was established by the 1985
amendments to the Act (Sect. 13(e)) and is required, by law, to provide
specific information to the research community. As stated above, one of
these requirements is minimizing pain or distress in the animals used in
research when possible. This publication provides a list of published
reference sources on Analgesia and the use of analgesics in animals. While
this publication is not meant to be a complete resource on the subject of
Analgesia and analgesics in animals it is hoped that it will be useful to
those involved with animal research and will be of assistance to the
investigators, veterinarians, and in the reduction of pain and distress to
these animals.
Analgesia : Pain and Distress : Animal Welfare Information Center
This bibliography that provides a review of literature (1992 to 2000) on anesthesia and Analgesia. Click on the species listed for an overview of literature (from 2000 to the present) on anesthesia and Analgesia of:
National Institutes of Health -- Gender and Pain: Scientific Abstracts
Recently, we have reported Analgesia to vaginal and cervical self-stimulation in women diagnosed with "complete" spinal cord injury at T-10 and higher, which is above the known level of entry into the spinal cord of both these nerves. We hypothesized a genital sensory role for vagus nerves to account for this unexpected finding. Supporting evidence was that brain mediated responses to VS (measured as pain thresholds and pupil dilatation) were reduced but not abolished by pelvic-hypogastric nerve transection bilaterally, or by surgical total transection of the spinal cord at T-7, and subsequent bilateral vagotomy abolished these responses. As further supporting evidence, on the basis of preliminary findings based on P.E.T. M.R.I. methodology in women with complete spinal cord injury above T-10, the region of the medulla oblongata to which the vagal afferents project (Nucleus of the Solitary Tract) is activated during cervical self-stimulation. These findings suggest that the vagus nerves provide a spinal cord bypass pathway mediating genital stimulation-produced Analgesia. This is consistent with studies by others that vagal electrical stimulation can produce Analgesia.
Rates of caesarean section and instrumental vaginal delivery in nulliparous women after low concentration epidural infusions or opioid analgesia: systematic review
When we excluded data for women who had labour induced and those who had elective forceps delivery, the risk was higher but not significant (2.11, 0.96 to 4.65; fig 3 ). Total operative delivery was higher with epidural Analgesia (1.63, 1.09 to 2.42). This risk was slightly reduced when we excluded the two trials with elective forceps deliveries and forceps deliveries for training purposes (1.55, 1.03 to 2.32). Epidural Analgesia was associated with a longer second stage of labour (weighted mean difference 15.2 minutes, 2.1 to 28.2 minutes). Non-compliance with allocated Analgesia was much less with epidural Analgesia (0.19, 0.11 to 0.33). Fewer women changed from the epidural group to the opioid group than vice versa (0.10, 0.05 to 0.22).
NIDA Research Expands Horizon for Analgesia Alternatives
A main focus of NIDA-supported Analgesia research is to develop medications that relieve pain without producing unwanted side effects. Opiate analgesics such as morphine are among the most effective medications currently available for treating long-term pain. Nonetheless, because many opiates have addictive side effects, physicians often under-prescribe them because they or their patients fear that the use of these medications could lead to opiate addiction. These perceptions linger even though studies have found that the fear of becoming addicted to opiates used clinically to treat pain is unfounded. (See "Pain Relief vs. Physical Dependency and Addiction: A Doctor's Dilemma," NIDA NOTES, July/ August 1993, p. 13.)
Energy Citations Database (ECD) - - Document #5862953
This study was conducted to determine whether exposure to RFR might induce sufficient thermal stress to activate endogenous opioid mechanisms and induce Analgesia.^Male Swiss Webster mice, 20-25 g, were exposed to 10, 15 or 20 mV/ cm{sup 2} RFR in a 2,450-MHz waveguide system for 10 min, then tested in the abdominal constriction paradigm.^Specific absorption rates (SAR) were 23.7 W/ kg at 10 mW/ cm{sup 2}, 34.6 W/ kg at 15 mW/ cm{sup 2} and 45.5 W/ kg at 20 mW/ cm{sup 2}.^Confinement in the exposure chamber alone did not appreciably alter body temperature but did appear to induce a stress-associated Analgesia that was insensitive to the opioid receptor blocker naltrexone.^Exposure of confined mice to RFR elevated body temperature and further increased Analgesia in SAR-dependent manner.^The high-SAR RFR-induced Analgesia, but not the hyperthermia, was reduced by naltrexone.^These findings suggest that (1) RFR produces SAR-dependent hyperthermia and Analgesia and (2) RFR-induced Analgesia is mediated by opioid mechanisms while confinement-induced Analgesia involves non-opioid mechanisms.
New Jersey Division of Consumer Affairs State Board of Dentistry Proposal - October 7, 2002
The following is a summary of the amendments and new rule which the Board is reproposing at this time. The proposed amendments to N.J.A.C. 13:30-1A.2 and 2.4 expand the scope of practice for licensed dental hygienists and registered dental assistants, respectively. N.J.A.C. 13:30-1A.2(c) and 2.4(b) provide that a licensed dental hygienist or a registered dental assistant, practicing under the direct supervision of a licensed dentist pursuant to the requirements of proposed new rule N.J.A.C. 13:30-8.20, may monitor a patient to whom the supervising dentist has administered nitrous oxide under limited circumstances. N.J.A.C. 13:30-2.4(b) specifies, however, that the registered dental assistant may not engage in any other permitted activity while monitoring the patient. The proposed amendments provide that a licensed dental hygienist or a registered dental assistant practicing under direct supervision may monitor a patient receiving Analgesia provided that the hygienist or the dental assistant has completed a Board-approved course in nitrous oxide/ oxygen inhalation Analgesia offered in a college or university clinical or hospital setting. The course must be submitted to the Board for review and approval of course content, be at least 14 hours in length and must include seven hours of didactic training and seven hours of clinical training, with a minimum of 10 monitored administrations of the Analgesia. The hygienist or the dental assistant must also maintain current certification in basic or advanced cardiac life support, and must complete a three hour didactic or clinical course in nitrous oxide/ oxygen inhalation Analgesia in each registration renewal period. Such re-certification course is required in addition to current continuing education requirements. In addition, the hygienist or the registered dental assistant is required to maintain and monitor the therapeutic level of the Analgesia administered by the supervising dentist and he or s
Definition of patient-controlled analgesia - NCI Dictionary of Cancer Terms
patient-controlled Analgesia
Management of Postoperative Pain - THORAX (NON-CARDIAC SURGERY - Thoracotomy
Brichon et al., 1994 ). Mixing a local anesthetic with an opioid produces better and more prolonged Analgesia, but randomized controlled trials indicate that there is a tendency toward more side effects when an opioid is added to a local anesthetic as compared to local anesthetic alone ( Mahon et al., 1999 ). The addition of local anesthetics to epidural opioids allows a significant reduction in the total opioid required to produce equivalent Analgesia ( Burgess et al., 1994 ). However, reliance on local anesthetics alone to secure postoperative epidural Analgesia in the thoracic region may be associated with hypotension due to sympathetic blockade. Epidural opioids may be delivered via either a lumbar or thoracic approach ( Gaeta et al., 1995 ). Lumbar epidural opioids have been used successfully to provide Analgesia but are less effective than thoracic administration. An example of a coordinated approach to postoperative Analgesia following thoracic surgery is the placement of an epidural catheter prior to induction of anesthesia. This catheter may be used to deliver local anesthetic, either alone or mixed with an opioid for intraoperative Analgesia. The catheter may then be left in place postoperatively for infusion of an analgesic solution containing either a local anesthetic, an opioid, or a combination of the two, delivered either as a continuous infusion or patient-controlled epidural Analgesia. The patient is then switched to patient-controlled Analgesia or oral analgesics if the epidural catheter ceases to function or is discontinued after several days.
2008 MeSH Tree Structures. E03 - Anesthesia and Analgesia
2008 MeSH Tree Structures. E03 - Anesthesia and Analgesia
Management of Postoperative Pain - SURGERY OF EXTREMITIES/VASCULAR SURGERY - Total Hip Replacement
At rest, epidural Analgesia is slightly better than IV patient-controlled Analgesia ( Wulf et al., 1999 ). Intrathecal administration of morphine in small doses is capable of providing excellent Analgesia ( Slappendel et al., 1999 ). The choice of fentanyl or morphine along with bupivicaine does not appear to make a significant difference in postoperative pain relief or side effects ( Berti et al., 1998 ). Continuous spinal anesthesia may provide more complete Analgesia and less muscle spasm than epidural Analgesia ( Mollmann et al., 1999 ). Intrathecal clonidine is capable of prolonging the duration of spinal anesthesia, but is markedly inferior to intrathecal morphine in providing subsequent postoperative Analgesia ( Fogarty et al., 1993 ). Administration of ketorolac tromethamine to patients receiving intrathecal opiates for postoperative pain control will reduce the need for additional opiates, but will not change the incidence of side effects ( Fogarty et al., 1995 ).
qb9421
1 NAL Call. No.: SF601.A47
Acetaminophen toxicosis: a potential model for acute liver failure in swine.
Artwohl, J.E.; Henne-Bruns, D.; Carter, E.; Cera, L.M.
Manhattan, Kan. : American Academy of Veterinary and Comparative Toxicology;
1988 Aug.
Veterinary and human toxicology v. 30 (4): p. 324-328. ill; 1988 Aug.
Includes references.
Language: English
Descriptors: Pigs; Analgesics; Poisoning; Liver function; Biopsy
2 NAL Call. No.: SF601.A46
Acupuncture for the treatment of chronic back pain in 200 horses.
Martin, B.B. Jr; Klide, A.M.
Lexington, Ky. : The Association; 1992.
Proceedings of the annual convention of the American Association of Equine
Practitioners (37): p. 593-601; 1992. Meeting held December 1-4, 1991, San
Francisco, California. Includes references.
Language: English
Descriptors: Horses; Acupuncture; Pain
3 NAL Call. No.: SF910.P34A55 1992
Acute pain from castration and tail docking of lambs.
Molony, V.; Wood, G.N.
New York : Churchill Livingstone; 1992.
Animal pain / edited by Charles E. Short, Alan Van Poznak. p. 385-395,
400-401; 1992. Includes references.
Language: English
Descriptors: Lambs; Pain; Tail; Cutting; Castration; Anesthesia; Local
anesthesia; Xylazine; Morphine; Etorphine; Naloxone; Drug effects
4 NAL Call. No.: 41.8 R3224
Alleviation of postanesthetic hypoxemia in the horse.
McMurphy, R.M.; Cribb, P.H.
Ottawa : Canadian Veterinary Medical Association; 1989 Jan.
The Canadian veterinary journal v. 30 (1): p. 37-41; 1989 Jan. Includes
references.
Language: English
Descriptors: Horses; Anesthesia; Adverse effects; Hypoxia; Therapy; Oxygen;
Partial pressure
5 NAL Call. No.: 442.8 J8222
Alterations in pituitary gland sensitivity in ram lambs to physiological doses
of gonadotrophin-releasing
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