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NIH - Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Information Page
Amyotrophic Lateral Sclerosis Information Page: National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological
disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. In ALS, both the upper motor neurons and the lower motor neurons degenerate
or die, ceasing to send messages to muscles. Unable to function, the muscles gradually weaken, waste away, and twitch. Eventually
the ability of the brain to start and control voluntary movement is lost. Individuals with ALS lose their strength and the
ability to move their arms, legs, and body. When muscles in the diaphragm and chest wall fail, individuals lose the ability
to breathe without ventilatory support. The disease does not affect a person's ability to see, smell, taste, hear, or recognize
touch, and it does not usually impair a person s thinking or other cognitive abilities. However, several recent studies suggest
that a small percentage of patients may experience problems with memory or decision-making, and there is growing evidence
that some may even develop a form of dementia. The cause of ALS is not known, and scientists do not yet know why ALS strikes
some people and not others.
Amyotrophic Lateral Sclerosis Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological
disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. The disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons.
Amyotrophic lateral sclerosis - Genetics Home Reference
Each type of familial Amyotrophic Lateral Sclerosis is caused by mutations in a specific gene. Type 1 is caused by mutations in the SOD1 gene, type 2 by ALS2 mutations, type 4 by mutations in the SETX gene, and type 8 by VAPB mutations. It is unclear how mutations in these genes contribute to the death of motor neurons, which leads to muscle weakness and atrophy. Research findings suggest that these mutations lead to the production of toxic substances or clumps (aggregates) of misshapen proteins that accumulate and damage motor neurons. Another possible effect is the altered development of axons, the specialized extensions of nerve cells (such as motor neurons) that transmit nerve impulses. The altered axons may impair transmission of impulses from nerves to muscles, which leads to muscle weakness and atrophy. Other genes are thought to cause familial Amyotrophic Lateral Sclerosis, but they have not been identified or fully characterized.
MedlinePlus Interactive Tutorials: Amyotrophic Lateral Sclerosis
MedlinePlus Interactive Tutorials: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Overview -- GeneReviews -- NCBI Bookshelf
Disease characteristics. Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease involving both the upper motor neurons (UMN) and lower motor neurons (LMN). UMN signs include hyperreflexia, extensor plantar response, increased muscle tone, and weakness in a topographical representation. LMN signs include weakness, muscle wasting, hyporeflexia, muscle cramps, and fasciculations. In the early stage of the disease, the clinical aspects of ALS can vary. Affected individuals typically present with asymmetric focal weakness of the extremities (stumbling or poor handgrip) or bulbar findings (dysarthria, dysphagia). Other findings include muscle fasciculations, muscle cramps, and lability of affect but not necessarily mood. Regardless of initial symptoms, atrophy and weakness eventually affect other muscles. The mean age of onset of ALS in individuals with no known family history is 56 years and in individuals with more than one affected family member (familial ALS or FALS) is age 46 years. In sporadic ALS, more men are affected than women and men may have an earlier disease onset. Average duration of the disease is about three years but can vary significantly. Death usually results from compromise of the respiratory muscles.
ClinicalTrials.gov - Information on Clinical Trials and Human Research Studies: Trial List
Is There a Higher Than Expected Occurrence of Amyotrophic Lateral Sclerosis (ALS) Among Deployed Veterans as Compared to Non-Deployed Gulf War Veterans?
OMIM - AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1
OMIM - Amyotrophic Lateral Sclerosis 1; ALS1
MedlinePlus: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. These neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. At first, this causes mild muscle problems. Some people notice
Search of: Open Studies | "Amyotrophic Lateral Sclerosis" - List Results - ClinicalTrials.gov
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis
Clinical Study: 06-N-0174, Cortical Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
Brooks BR, Miller RG, Swash M, Munsat TL; World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9.
healthfinder.gov — Amyotrophic Lateral Sclerosis Association - ALSA
The ALS Association is the only national not-for-profit health organization dedicated solely to the fight against ALS. ALS covers all the bases-research, patient and community services. ALS clinical service centers nationwide, public education, and advocacy-in providing help and hope to those facing the disease. The mission of the ALS Association (ALSA) is to find a cure for and improve living with Amyotrophic Lateral Sclerosis.
ATSDR - Multiple Sclerosis and Amyotrophic Lateral Sclerosis
Residents of communities living near hazardous waste sites have expressed concern about elevated rates of neurological conditions such as multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS) and possible associations with environmental exposures. The absence of population-based registries for these diseases complicates the task of enumerating cases in a community, and limits the ability of local, state, and federal public health agencies to respond to these concerns.
NIH Guide: AMYOTROPHIC LATERAL SCLEROSIS
announcement, Amyotrophic Lateral Sclerosis, is related to the
Amyotrophic Lateral Sclerosis Study (ALSS)
The Amyotrophic Lateral Sclerosis (ALSS) Study was conducted in New England with the intent to characterize the potential associations of ALS with the following:
ATSDR - Motor Neuron Disease/Amyotrophic Lateral Sclerosis: Preliminary Review of Environmental Risk Factors and Mortality in Bexar County, Texas
Non-ionizing radiation, particularly from power frequency electric and magnetic fields, has also been evaluated as a risk factor for MND. Previous reports suggested an association between Amyotrophic Lateral Sclerosis and occupations with potential electromagnetic field exposure. Reviews of cohorts in both the United States and Denmark found a greater risk for MND among electrical utility employees that would have opportunities for exposure to electromagnetic fields (78-80). A clinic-based study in Sweden found elevated risks for ALS among individuals with the highest magnetic field exposure (81). Other case-control studies in the United States and Sweden also observed significantly elevated risk for MND among individuals employed in electrically-related occupations (26, 34, 65, 82). Finally, a survey in Scotland found a higher proportion of electrical and electronic workers among MND cases when compared with the distribution of occupations in the general population (70). The observed cases with these occupations were too small to make valid statistical comparisons, and a similar review of occupations among MND deaths in England and Wales did not find a greater than expected proportion of electrical and electronic workers (67, 70).
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis - References - Genetics Home Reference
Chen YZ, Bennett CL, Huynh HM, Blair IP, Puls I, Irobi J, Dierick I, Abel A, Kennerson ML, Rabin BA, Nicholson GA, Auer-Grumbach M, Wagner K, De Jonghe P, Griffin JW, Fischbeck KH, Timmerman V, Cornblath DR, Chance PF. DNA/ RNA helicase gene mutations in a form of juvenile Amyotrophic Lateral Sclerosis (ALS4). Am J Hum Genet. 2004 Jun;74(6):1128-35. Epub 2004 Apr 21.
ALS Amytrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease,
that is, a disease that affects the skeletal muscle nerve cells. A network
of nerves carries messages from the brain, down the spinal cord and out to
various parts of the body. Included in this network are motor neurons which
carry messages to the skeletal muscles. In ALS, these nerves progressively
degenerate and eventually die. As a result, the skeletal muscles do not receive
the nerve signals they need to function properly and the muscles gradually
atrophy or waste away from lack of use, leaving parts of the body paralyzed.
healthfinder.gov - Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for contr ... Details >
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