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Screening for fetal chromosomal abnormalities.
This guideline updates a previous version: American College of Obstetricians and Gynecologists (ACOG). Prenatal diagnosis of fetal chromosomal Abnormalities. Washington (DC): American College of Obstetricians and Gynecologists (ACOG); 2001 May. 12 p.(ACOG practice bulletin; no. 27).
genome.gov | Chromosome Abnormalities Fact Sheet
Maternal Age: Women are born with all the eggs they will ever have. Therefore, when a woman is 30 years old, so are her eggs. Some researchers believe that errors can crop up in the eggs' genetic material as they age over time. Therefore, older women are more at risk of giving birth to babies with chromosome Abnormalities than younger women. Since men produce new sperm throughout their life, paternal age does not increase risk of chromosome Abnormalities.
MedlinePlus
Medical Encyclopedia: Nail abnormalities
Nail Abnormalities are problems with the color, shape, texture, or thickness of the fingernails or toenails.
Chromosome abnormalities
Chromosome Abnormalities might be defined as changes resulting in a visible alteration of the chromosomes. How much can be seen depends on the technique used. The smallest loss or gain of material visible by traditional methods on standard cytogenetic preparations is about 4 megabases of DNA. However, fluorescence in situ hybridization (FISH, Section 10.1.4 ) allows much smaller changes to be seen; the development of molecular cytogenetics has removed any clear dividing line between changes described as chromosomal Abnormalities and changes thought of as molecular or DNA defects. An alternative definition of a chromosomal abnormality is an abnormality produced by specifically chromosomal mechanisms. Most chromosomal aberrations are produced by misrepair of broken chromosomes, by improper recombination or by malsegregation of chromosomes during mitosis or meiosis.
Diagnosis and Management of Specific Breast Abnormalities: Structured Abstract
Conclusions: The best available evidence suggests that breast symptoms are evaluated initially by clinical breast exam and imaging study, with supplemental studies when the diagnosis is unclear. There is no evidence to support modifying the work-up of breast symptoms or mammographic Abnormalities based on risk factors other than age.
Search of: "Abnormalities" - List Results - ClinicalTrials.gov
DiGeorge Syndrome; Shprintzen Syndrome; Chromosome Abnormalities; Abnormalities, Multiple; Conotruncal Cardiac Defects
Energy Citations Database (ECD) - - Document #198088
Pleural Abnormalities identified on anatomical studies are often nonspecific and may represent benign or malignant disease. We prospectively evaluated the ability of FDG-PET to identify malignancy in patients with pleural Abnormalities detected on chest radiographs or chest CT. Thirty-two patients with pleural Abnormalities (pleural masses, thickening or effusions) found on chest radiographs or CT were evaluated by FDG-PET. Regions of interest (ROI) were identified on the PET images correlating to anatomic Abnormalities and standard uptake ratios (SUR`s) of these ROI`s were calculated. A SUR value of 2.5 or greater was considered positive for malignancy. Physicians blinded to biopsy results graded their confidence of malignancy (1-5 scale) and graded lesion FDG uptake with respect to mediastinal radioactivity. Twenty-three of the patients had definitive diagnoses by tissue biopsy. Seventeen of these patients had malignant (SUR=7.9{plus_minus}3.8) and 6 had benign (SUR=2.8{plus_minus}2.4) causes of their pleural Abnormalities (p=0.001). All but two malignant cases had SURs higher than 2.5 and one of these two was correctly interpreted by the observers. SURs lower than 2.5 were seen in four of the six (67%) benign pleural Abnormalities. Using a combination of both visual and semiquantitative analysis, the sensitivity of FDG-PET for detecting malignant pleural Abnormalities was 94%. Active infections in the pleural space had increased FDG uptake on PET studies while other benign pleural Abnormalities did not. FDG-PET has very high sensitivity for detecting malignant pleural Abnormalities and can differentiate benign from malignant pleural Abnormalities.
Search of: "Congenital Abnormalities" - List Results - ClinicalTrials.gov
DiGeorge Syndrome; Shprintzen Syndrome; Chromosome Abnormalities; Abnormalities, Multiple; Conotruncal Cardiac Defects
MedlinePlus
Medical Encyclopedia: Walking abnormalities
The physical examination will probably include neurological examination. Diagnostic tests will be determined by the results of the physical examination workup and observation of the gait Abnormalities.
FloridaHealthFinder.gov | Health Encyclopedia | Walking abnormalities
The physical examination will probably include neurological examination. Diagnostic tests will be determined by the results of the physical examination workup and observation of the gait Abnormalities.
eLCOSH : Abnormalities Consistent with Asbestos-Related Disease Among Long-Term Demolition Workers
The presence of findings on chest X-rays consistent with asbestos-related scarring was associated with abnormality on pulmonary function testing (table 9) . Fifty-four (79 percent) of 68 examinees with normal chest X-rays had normal pulmonary function tests. Only nine (47 percent) of the 19 individuals with abnormal chest X-rays exhibited normal pulmonary function. This difference was found entirely in the rates of restrictive Abnormalities. For those with normal films, the rate of restrictive change was 12/ 68 (18 percent); for those with X-ray Abnormalities, the rate was 10/ 19 (53 percent). None of the subjects with abnormal chest X-rays had a purely obstructive pulmonary function pattern.
NHLBI, Estimate of 10-Year Risk for CHD
NHLBI, Estimate of 10-Year Risk for CHD
Chromosome abnormalities
Question: Advanced Placement Biology students are looking for information on XXX chromosome Abnormalities and Xyy chromosome Abnormalities. Looking for prevalence, causes, treatment, prognosis. Can anyone give us information? Betty A Laliberte Thanks.
Search Results - Genetics Home Reference
Related classification: Abnormalities, Multiple
Search Results - Genetics Home Reference
Related classification: Abnormalities, Multiple
NIH Guide: RESEARCH ON THE HEMATOLOGIC ABNORMALITIES IN AIDS
Numerous hematologic Abnormalities arise in individuals following HIV Infection, many of which may cause life-threatening symptoms or may impair the quality of life of these patients. Understanding how these Abnormalities arise may be complicated by a variety of other infections, in addition to HIV, which usually are seen in these patients. Bone marrow dysplasia, anemia, thrombocytopenia, and leukopenia occur frequently in patients with HIV infection. Both ineffective hematopoiesis and peripheral destruction of blood cells may lead to cytopenia common in AIDS patients. The latter condition may be due to accelerated utilization and destruction of cells due to opportunistic infections, reticuloendothelial cell dysfunction, or to specific autoimmunity. Ineffective hematopoiesis in patients with AIDS has several potential causes which may include, for example: (1) Suppression of the bone marrow by the HIV infection through abnormal cytokine expression and alteration of the bone marrow environment; (2) the formation of circulating inhibitors; and (3) the effects of HIV on hematopoietic stem cells. The recent development of new technologies to make recombinant human hematopoietic growth factors has made it possible to correct some of the cytopenias associated with HIV infection and has also fostered studies of the role of growth factors in hematopoiesis, both in vitro and in vivo.
Fish and Wildlife Service
B. Background: There is variability in what researchers term "abnormal" when reporting the prevalence of abnormal frogs. Researchers who focus on the prevalence of skeletal and eye Abnormalities often exclude traumatic injuries, diseases, and surficial Abnormalities or infections from their reports (Eaton et al. 2004; Helgen et al. 2000; Hoppe, 2000; Hoppe, 2005; Johnson et al. 2001; Levey 2003; Ouellet et al. 1997; Schoff et al. 2003, Taylor et al. 2005). Other researchers include Abnormalities and diseases but not obvious injuries when reporting the prevalence of abnormal frogs (McCallum and Trauth 2003), and still others report all gross physical Abnormalities (Dubois 1979; Johnson et al. 2002; Lannoo et al. 2003). Because of this variability, a decision was made in the USFWS Abnormal Amphibian surveys to categorize frogs with any gross physical abnormality as “abnormal” to ensure consistency in field data collection (USFWS 1999). Consequently, the results from our surveys include more Abnormalities than are reported by most researchers studying abnormal frogs. We developed this abnormal classification standard operating procedure (SOP) to enable a more accurate comparison of our field data with published research. Regional amphibian coordinators will utilize this SOP to further refine our “abnormal” category and ensure consistency in our classification of abnormal frogs. The SOP combines Abnormalities into categories and subcategories, which may stem from similar causes, and provides us with more power to detect relationships between environmental variables and certain types of Abnormalities. The abnormality classification SOP has its origins in the Field Guide to Malformations of Frogs and Toads with Radiographic Interpretations (Meteyer, 2000), which describes malformations in detail with photographs and radiographs, and in the body of literature cited above. Additional
NIH Guide: RESEARCH ON THE HEMATOLOGIC ABNORMALITIES IN AIDS
National Institute of Diabetes and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute (NHLBI) invite grant applications for support of research addressing fundamental questions of hematologic Abnormalities exhibited by humans infected by Human Immunodeficiency Viruses (HIV), the infectious agents of Human Acquired Immunodeficiency Syndrome (AIDS). Hematologic Abnormalities in patients with the HIV infection are common. These Abnormalities can significantly impact on the course of treatment for thesepatients. Fundamental progress has been made in the understanding of the molecular biology and clinical aspects of retroviral infection. It has become clear that further studies of retroviral-induced neoplasms of immunodeficiency states will continue to provide useful new information about the cellular and humoral basis of the immune responses, including the mechanisms leading to hematologic Abnormalities which are seen following HIV infection. This announcement is intended to solicit applications for support of studies on the cellular basis of these hematologic Abnormalities. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. Potential applicants may obtain a copy of "Healthy People 2000 (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No.017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agen
Sacral hemangiomas multiple congenital abnormalities
PubMed lists journal articles that discuss Sacral hemangiomas multiple congenital Abnormalities. Click on the link to go to PubMed and review citations to these articles.
Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study
The current data suggest a greater vulnerability to develop metabolic Abnormalities for patients diagnosed with schizophrenia when compared to the general population. A higher prevalence of metabolic Abnormalities was already present in the age-band between 15 and 25 years old and increased with increasing age and duration of illness, which suggests a direct impact of the illness and/ or negative metabolic side-effects of antipsychotic medication. The suggestion of a direct impact of the illness of schizophrenia and/ or its pharmacological treatment on the development of metabolic Abnormalities is in line with another Belgian study (BEST, i.e. "Belgian Evaluation of Screening and Treatment of high risk patients based on waist and age") [ 50 ]. This study was recently performed in 8,587 middle-aged (40 75 years) individuals without any cardiovascular history, consecutively selected by general practitioners upon a moderately increased waist circumference ( 80 cm in women and 94 cm in men). In this survey, 25 % of the non-diabetic population had the metabolic syndrome according to NCEP-ATP III criteria, thus a much lower prevalence than the 36.7 % observed in the subgroup of patients with the longest duration of the illness. This difference is striking since the subjects of BEST were older (61 vs 50 years) and had a much higher BMI (31.8 vs 26.6 kg/ m 2 ) when compared to the patients with chronic schizophrenia in our sample, obviously due to selection criteria. Furthermore, in the subgroup with the longest duration of illness, the prevalence of diabetes (16.5%) was almost similar to that observed in the non-psychiatric population of the BEST study (18%), despite a 10 year younger age and a 5 kg/ m2 lower BMI. These findings support a deleterious metabolic effect of the illness of schizophrenia itself and/ or antipsychotic medication.
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